Chemical Structural Effects of Amphipathic and Water-soluble Phospholipid Polymers on Formulation of Solid Dispersions

For the polymeric carriers of solid dispersions, it is important that themselves dissolve quickly and maintain supersaturated state amorphous drugs during their dissolution period to improve bioavailability. Amphipathic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers can be dissolved in water, owing extremely high hydrophilicity MPC units, are used as an ideal feeder for drug molecules form aggregates aqueous conditions. We synthesized amphipathic copolymers with different hydrophobic side chains molar ratios evaluated effect on rate supersaturation maintenance dispersions indomethacin. In most water-soluble copolymers, “spring-parachute”-like behavior was observed, where initially became followed by slow precipitation. particular, aromatic rings or a percentage units remained longer period. contrast, urethane groups, which hydrogen bonds molecules, could also interact water were not conducive maintaining supersaturation. addition, solubility polymer rapid dissolution.